Flutriafol is one of the 84 substances of the third stage part B of the review programme . In accordance with the Regulation, at the request of the Commission of the European Communities, the EFSA organised a peer review of the initial evaluation,, provided by the United Kingdom, being the designated rapporteur Member State (RMS). The peer review process was subsequently terminated following the applicant’s decision.

One of the important applications of Flutriafol(CAS NO: 76674-21-0) is Fertiliser Application. Treated fertiliser should be sown in the same furrow as the seed, not broadcast. Note that the flow rate of fertiliser may be changed after treatment, and the seeder should be calibrated with the treated material to ensure that the correct rates of fertiliser and fungicide are delivered. Do not mix seed with treated fertiliser. 

Data gaps were identified in the section identity, physical and chemical properties of the active substance and analytical methods. Data gaps were also identified in the mammalian toxicology section to address the relevance of the impurities present in the technical specification, to set reference values for the plant metabolites triazole alanine and triazole acetic acid, and to characterise the isomer ratio found in residues to which workers are exposed. 

The conclusions laid down in this report were reached on the basis of the evaluation of the representative uses of flutriafol as a fungicide on wheat, as proposed by the applicant. Full details of the representative uses can be found in Appendix A to this report. 

Flutriafol(CAS NO: 76674-21-0) is very stable in soil and the aquatic environment. It is expected to exhibit medium to high mobility in soil. A critical area of concern has been identified for potential groundwater contamination. 

Two data gaps were identified in the ecotoxicology section. Further information should be provided to address the long-term risk to insectivorous birds. The ecotoxicological relevance of the impurities should be addressed. A high long-term risk to insectivorous birds was identified, based on the available data.

Based on the metabolism studies conducted on cereals, oilseed/pulse crops and root crops, the residue for monitoring was limited to the parent flutriafol only. Two separate definitions were proposed for risk assessment; 1) flutriafol and 2) Triazole derivative metabolites (TDM), since TDM were seen to be present in significant proportions and levels in primary and rotational crops. A default MRL value of 0.05 mg/kg was proposed for the crops usually rotated with wheat as there is clear evidence that residues above 0.01 mg/kg are expected in rotational crops. 

No residue definition could be proposed for animal products and a new metabolism study on ruminant was identified as a data gap. A data gap was also identified concerning the TDM, since no information was provided to include these metabolites in the consumer risk assessment. 

Want to learn more information about Flutriafol, you can access the guidechem.com. 

Pitavastatin calcium is an inhibitor of HMG-CoA reductase. It is a synthetic lipid-lowering agent for oral administration.The empirical formula for pitavastatin is C50H46CaF2N2O8 and the molecular weight is 880.98. The CAS NO is 147526-32-7.

Pitavastatin calcium is odorless and occurs as white to pale-yellow powder. It is freely soluble in pyridine, chloroform, dilute hydrochloric acid, and tetrahydrofuran, soluble in ethylene glycol, sparingly soluble in octanol, slightly soluble in methanol, very slightly soluble in water or ethanol, and practically insoluble in acetonitrile or diethyl ether. Pitavastatin is hygroscopic and slightly unstable in light.

Pitavastatin calcium (previously known as itavastatin, itabavastin, nisvastatin) was discovered in Japan by Nissan Chemical Industries and developed further by Kowa Pharmaceuticals, Tokyo. Pitavastatin was approved for use in the United States by the FDA on 08/03/2009 under the trade name Livalo. It has been also approved by the Medicines and Healthcare products Regulatory Agency (MHRA) in UK on 17 August 2010.

Pitavastatin calcium (CAS NO:147526-32-7)is indicated for hypercholesterolaemia (elevated cholesterol) and for the prevention of cardiovascular disease. A 2009 study showed that pitavastatin increased HDL cholesterol (24.6%), especially in patients with HDL lower than 40 mg/dl, in addition to greatly reducing LDL cholesterol (31.3%). As a consequence, pitavastatin is most likely to be appropriate for patients with metabolic syndrome with high LDL, low HDL and diabetes mellitus.

Most statins are metabolised in part by one or more hepatic cytochrome P450 enzymes, leading to an increased potential for drug interactions and problems with certain foods (such as grapefruit juice). Pitavastatin calcium appears to be a substrate of CYP2C9, and not CYP3A4 (which is a common source of interactions in other statins). As a result, it is less likely to interact with drugs that are metabolized via CYP3A4, which might be important for elderly patients who need to take multiple medicines.

Common statin-related side-effects (headaches, stomach upset, abnormal liver function tests and muscle cramps) were similar to other statins. However, Pitavastatin calcium seems to lead to fewer muscle side effects than other statins, since coenzyme Q10 is not significantly reduced. Hyperuricemia or increased levels of serum uric acid have been reported with pitavastatin. Pitavastatin calcium interactions have: Muscular Weakness, Malaise, Hepatic Function Abnormal, Constipation, Gamma-glutamyltransferase Increased, Blood Lactate Dehydrogenase Increased, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Vomiting, Pyrexia.

Want to learn more information about Pitavastatin calcium, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.

Benzyl chloroformate is the benzyl ester of chloroformic acid. It is also known as benzyl chlorocarbonate and is an oily liquid whose color is anywhere from yellow to colorless. It is also known for its pungent odor. When heated, benzyl chloroformate decomposes into phosgene and if it comes in contact with water it produces toxic, corrosive fumes. The CAS NO is 501-53-1. Benzyl chloroformate is used in organic synthesis for the introduction of the carboxybenzyl protecting group for amines.The newly formed Cbz protecting group can be removed under reductive conditions. Typically hydrogen gas and activated palladium on carbon is used.

Here are some Chinese suppliers information in guidechem, if you need some Benzyl Chloroformate, this article may useful for you.

The First supplier:

Benzyl chloroformate

Updatetime:Nov 29 2013

Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.

Tel:86-21-51950635

Address:Nianjiabang Rd, Pudong, Shanghai

The Second supplier:

Benzylchloroformate(CAS NO:501-53-1)

Updatetime:Oct 17 2013

DetailDesc:Our company keeps the business tenet of “people first and customer esteemed” and the service principle of “superior quality, reasonable price, good faith”. We insist on the principle of win-win cooperation and would like to create brilliant future hand in hand with you!

Tel:86-1383-5989052

Address:No.9, Haikou Road, Huai'an Industiral Park, Jiangsu Province, China

The Third supplier:

Benzyl chloroformate

Updatetime:Oct 31 2013

DetailDesc:Zhejiang Kaili Industrial Co., Ltd. is collect Science, Industrial and Trade together for a comprehensive high-tech entities. We are mainly engaged in the research, development, production and sales of APIs and pharmaceutical intermediates.

Tel:86-571-85241926

Address:Block C&D,12/F,Lantian Business Center,No.18 Moganshan Road,Hangzhou,China

The Forth supplier:

Benzyl Chloroformate

Updatetime:Jul 19 2013

Purity:99

DetailDesc: benzyl chloroformate Chinese alias phenylmethoxy chloride CAS RN 501-53-1 EINECS No. 207-925-0 Molecular formula C8H7ClO2 Molecular Weight 170.59 Properties colorless oily liquid, rancid odor. Boiling point 103 C(2666Pa) The relative density of 1.20 Refractive index of 1.5160 Flash point 91 C Solubility soluble in ether, acetone, benz...

Tel:86-135-15431451

Address:428 Daixi Third Road Zouping County Shandong Province China

The Fifth supplier:

Benzyl chloroformate

Updatetime:Jun 07 2013

DetailDesc: EC NO:207-925-0 MF:C8H7ClO2 Synonyms:benzyl chlorocarbonate;BENZYL CHLOROFORMATE (BCF);carbobenzoxy chloride;Carbonochloridic acid, phenylmethyl ester;Carbonochloride acid benzylester; Benzyl Chloroformate,Carboobenzoxy Chloride;

Address:Room 403, Hauli Bldg, 6 Gongnong Road, Nantong, China

The sixth supplier:

Benzyl chloroformate

Updatetime:Dec 02 2013

DetailDesc:Benzyl chloroformate

Tel:86-571-88938639

Address:B/2601 Fuli Building, 328# WenEr Rd. Hangzhou City 310012 China

The seventh supplier:

Benzyl Chloroformate

Updatetime:Oct 06 2013

Tel:+86-755-33670265

Address:3/F Weiye Building, Niulanqian, Longhua Town, Bao'an District, ShenZhen, Guangdong, China

These are just some Chinese suppliers in guidechem, you can also find some other suppliers in any other countries, however if you have some Benzyl chloroformate to supply, you can also access this site, and post your supply information. Thank you, I hope my article can give you a little help.

Frankie is the freelance writer for e-commerce website in the chemistry. Guidechem.com is just a place for you to look for some chemicals. Our guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people.

Malathion is a man-made organophosphate insecticide that is commonly used to control mosquitoes and a variety of insects that attack fruits, vegetables, landscaping plants, and shrubs. It can also be found in other pesticide products used indoors and on pets to control ticks and insects, such as fleas and ants. 

Malathion(CAS NO:121-75-5) is the active ingredient in mosquitocontrol products including Fyfanon and Atrapa. These products contain over 95% malathion and are often applied undiluted. However, they may be diluted with a petroleum solvent similar to kerosene before application, in which case petroleum solvent will make up most of the pesticide solution.

Because pesticide products are inherently toxic, no pesticide exposure is risk free. The likelihood of experiencing adverse health effects from exposure to any pesticide, including malathion, depends primarily on the amount of pesticide that a person contacts and the amount of time the person is in contact with that pesticide. In addition, a person's age, sex, genetic makeup, life style and/ or general health characteristics can affect his or her likelihood of experiencing adverse health effects as a result of exposure to pesticides.

Malathion(CAS NO:121-75-5) is a pesticide that is widely used in agriculture, residential landscaping, public recreation areas, and in public health pest control programs such as mosquito eradication.In the US, it is the most commonly used organophosphate insecticide.

Malathion was used in the 1980s in California to combat the Mediterranean Fruit Fly. This was accomplished on a wide scale by the near weekly aerial spraying of suburban communities for a period of several months. Formations of three or four agricultural helicopters would overfly suburban portions of Alameda County, San Bernardino County, San Mateo County, Santa Clara County, San Joaquin County, Stanislaus County, and Merced County releasing a mixture of malathion and corn syrup, the corn syrup being a bait for the fruit flies. Malathion has also been used to combat the Mediterranean fruit fly in Australia.

Malathion was sprayed in many cities to combat West Nile virus. In the Fall of 1999 and the Spring of 2000, Long Island and the five boroughs of New York City were sprayed with several pesticides, one of which was malathion. While it was claimed by some anti-pesticide groups that use of these pesticides caused a lobster die-off in Long Island Sound, there is no conclusive evidence yet to support this.

Manitoba ordered the city of Winnipeg, Manitoba to be sprayed in July 2005 as part of the West Nile virus campaign. Prior to this, malathion was used over the last couple of decades on a regular basis during summer months to kill nuisance mosquitoes, but homeowners were allowed to exempt their properties if they chose. Today, Winnipeg is the only major city in Canada with an ongoing Malathion nuisance-adult-mosquito-control program.

Malathion is applied at very low concentrations to control mosquitoes.Malathion is unlikely that adverse health effects will occur as a result of this use for most people, but some individuals may experience health effects. For these reasons, individuals should consider taking steps to minimize their exposure to malathion if it is applied to control mosquitoes.

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 EINECS: 221-921-6

Molecular Formula: C5H9ClO
Molecular Weight: 120.58
Density: 0.979
Storage Temperature:Store at RT.
Solubility: Hydrolysis
Synonyms: pivaloyl chloride; Pivaloyl chloride; 2,2-Dimethyl-propanoyl chloride; PC
Stability: Stable under normal temperatures and pressures.
Appearance: colorless to yellow liquid
HS Code: 29159080
CAS Registry Number: 3282-30-2

Emergency overview of Trimethylacetyl chloride

Trimethylacetyl chloride(CAS NO:3282-30-2) is Dangerous, Flammable liquid and vapor. It is Water-reactive. Harmful if swallowed. Causes burns by all exposure routes. Toxic if inhaled. Target Organs: Respiratory system, gastrointestinal system, eyes, skin.

Potential Health Effects
Eye: Causes eye burns. Lachrymator (substance which increases the flow of tears). 
Skin: Causes skin burns. May be harmful if absorbed through the skin. 
Ingestion: Harmful if swallowed. Causes gastrointestinal tract burns. 
Inhalation: Causes chemical burns to the respiratory tract. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. Toxic if inhaled. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting. 
Chronic: No information found.

First Aid Measures of Trimethylacetyl chloride

Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. 
Skin: Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. 
Ingestion: Do not induce vomiting. Get medical aid immediately. Call a poison control center. 
Inhalation: Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Fire Fighting Measures

As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Water reactive. Material will react with water and may release a flammable and/or toxic gas. Containers may explode in the heat of a fire. Flammable liquid and vapor. Water hydrolyzes material liberating acidic gas which in contact with metal surfaces can generate flammable and/or explosive hydrogen gas.

Accidental Release Measures of Trimethylacetyl chloride

Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Wear a self contained breathing apparatus and appropriate personal protection. (See Exposure Controls, Personal Protection section). Remove all sources of ignition. Use a spark-proof tool. Do not expose spill to water. Do not get water inside containers. Do not let this chemical enter the environment.

Handling and Storage of Trimethylacetyl chloride

Handling: Use spark-proof tools and explosion proof equipment. Do not get Trimethylacetyl chloride in eyes, on skin, or on clothing. Keep Trimethylacetyl chloride away from heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. 
Storage: Keep Trimethylacetyl chloride away from sources of ignition.Store in a cool, dry place. Store in a tightly closed container. Flammables area. Water free area.

Want to learn more information about trimethylacetyl chloride, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals.

Basic properties of 2-fluoroaniline:

Category : Intermediates

EC NO : 261-034-1

MF : C6H5ClFN

MW : 145.56

Appearance: clear to brown liquid

Solubility: slightly soluble

Synonyms : 2-fluoro-4-chloroaniline;4-Chloro-2-fluoroaniline

Stability: Stable under normal temperatures and pressures.

CAS NO : 348-54-9

Toxic if inhaled.Harmful if swallowed.Harmful in contact with skin.Causes skin irritation.Causes serious eye irritation.Flammable liquid and vapour.May cause damage to organs through prolonged or repeated exposure.

Keep away from heat/sparks/open flames/hot surfaces. No smoking. Use explosion-proof electrical/ventilating/lighting/ equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.

Suppliers information of 2-fluoroaniline(CAS NO:348-54-9):

Suppliers information 1:

2-Fluoroaniline

Updatetime:Sep 23 2013

Purity:98% Supply Ability:g/kg 

DetailDesc:Atomax Chemicals Co.,Ltd a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. we are a registered chemicals provider for most giant pharmaceutical company like Merck, Pfizer, Novartis, Roche, Astrazeneca, Sanofi-Aventis, etc.

Tel:86-755-33239182

Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

Suppliers information 2:

2-Fluoroaniline

Updatetime:Oct 16 2013

Tel:86-21-12345678

Address:Lane No.36, Zhongke road 2195, Zhangjiang high-tech park, Pudong new area Shanghai, China

Introduction:Founded by a group of veterans from the US biopharmaceutical industry in 2010, P&T is now a leading Shanghai-based CRO company providing drug discovery and development services worldwide. With our technical expertise and excellent research facilities, we offer broad and integrated chemical synthesis (custom synthesis, library design and synthesis), medicinal chemistry.

Suppliers information 3:

2-Fluoroaniline

Updatetime:Nov 18 2013

DetailDesc: Molecular formula : C6H6FN MW : 111.1185 CAS No. :348-54-9 nature : light yellow transparent liquid, the temperature -29 C, the boiling point of 183 C, flash point of 66 C and relative density of 1.151, RI 1.5420

Tel:86-27-83229541

Address:Add: Room 303, Chuangye Building, Qixiong Rd., Wujiashan, Dongxihu District. WUHAN CHINA

Suppliers information 4:

2-Fluoroaniline

Updatetime:Jan 22 2013

Tel:+86-(21)-6427-9170

Address:Suite 22G, Shanghai Industrial Investment Bldg, 18 Caoxi Road, Shanghai 200030,

Introduction: Profile: Shanghai Freemen Chemicals Co., Ltd. offers agrochemical ingredients, food additives, water treatment chemicals, flavours,fragrances and intermediates. Water treatment chemicals include 2,2-dibromo-3-nitriloproptioamide, 1-bromo-3-chloro-5,5-dimethylhydantoin, benzyl triethyl ammonium chloride, glutaraldehyde and alkyl dimethyl ethylbenzyl ammonium chloride.

Suppliers information 5:

2-Fluoroaniline

Updatetime:Dec 04 2012

Tel:+86-(21)-52702636

Address:No.3 ,Lane 1273, Tong Pu Road, Shanghai 200333,

Introduction:Profile: Chemspec International Limited is a contract manufacturer of highly engineered specialty chemicals. We are specialized in manufacturing fluorinated specialty chemicals. Our specialty chemicals, typically highly engineered chemicals, are used as building blocks for more advanced chemicals or used to enhance the performance of the end products of our clients. 

Want to learn more information about 2-Fluoroaniline, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. 

Isoflavones comprise a class of organic compounds, often naturally occurring, related to the isoflavonoids. Many act as phytoestrogens in mammals. Some are termed antioxidants because of their ability to trap singlet oxygen. 

Some isoflavones(CAS NO:574-12-9), in particular soy isoflavones, when studied in populations eating soy protein, have indicated that there is a lower incidence of breast cancer and other common cancers because of its role in influencing sex hormone metabolism and biological activity through intracellular enzymes, protein synthesis, growth factor actions, malignant cell proliferations, differentation and angiogenesis.

They are acting as phytoestrogens that are thought of by some as useful in treating cancer.They are also very strong antioxidants.Critics of the inclusion of isoflavones in food claim that they increase the incidence of epithelial hyperplasia, which precedes cancerous tumors, and that they cause goitre and hyperthyroidism.Phytoestrogens may actually promote cancer.

Isoflavones(CAS NO:574-12-9) are produced from a branch of the general phenylpropanoid pathway that produces all flavonoid compounds in higher plants. Soybeans are the most common source of isoflavones and the major isoflavones in soybean are genistein and daidzein.

Research in several areas of healthcare has shown that consumption of isoflavones may play a role in lowering risk for disease. They can fight disease on several fronts. The following potential health benefits are attributed to isoflavones:

Reduce cancer risk

Isoflavones seem to be protect agains tumors because they act against cancer cells in a way similar to many common cancer-treating drugs. Population-based studies show a strong association between consumption of isoflavones and a reduced risk of breast and endometrial cancer. Women who ate the most soy products and other foods rich in isoflavones reduced their risk of endometrial cancer by 54%.

Protect against prostate problems

Isoflavones may be benificial for men's health because they may protect against enlargement of the male prostate gland. Studies show isoflavones slowed prostate cancer growth and caused prostate cancer cells to die. Isoflavones act against cancer cells in a way similar to many common cancer-treating drugs.

Reduce heart disease risk

Soy isoflavones also appear to reduce cardiovascular disease risk via several distinct mechanisms. Isoflavones inhibit the growth of cells that form artery clogging plaque. These arteries usually form blood clots which can lead to a heart attack. A review of 38 controlled studies on soy and heart disease concluded that soy is definitely effective for improving cholesterol profile. There is some evidence that isoflavones are the active ingredients in soy responsible for improving cholesterol profile.

Isoflavones improve bone health

Soy Isoflavones help in the preservation of the bone substance and fight osteoporosis. This is the reason why people in China and Japan very rarely have osteoporosis, despite their low consumption of dairy products, whereas in Europe and North America the contrary happens. Unlike estrogen, which helps prevent the destruction of bone, evidence suggests that isoflavones may also assist in creating new bone. Other studies are not entirely consistent, but evidence suggests that genistein and other soy isoflavones can help prevent osteoporosis.

Want to learn more information about Isoflavones, you can access the guidechem.com.

Empirical Formula: C10H19NO3 

Molecular Weight: 201.2628

IUPAC Name: tert-butyl 4-hydroxypiperidine-1-carboxylate   

Appearance: White to cream powder

storage temp. Store at -15 C 

Nominal Mass: 201 Da 

Average Mass: 201.2628 Da 

Monoisotopic Mass: 201.136493 Da 

Index of Refraction: 1.495 

Molar Refractivity: 53.03 cm3 

Molar Volume: 181.6 cm3 

Surface Tension: 42.5 

Density: 1.107 g/cm3 

Flash Point: 130.6  C 

Enthalpy of Vaporization: 61.7 kJ/mol 

Boiling Point: 292.3  C at 760 mmHg

CAS NO.: 109384-19-2

Usages:N-BOC-4-Hydroxypiperidine is used as pharmaceutical intermediate

Product Categories: Alcohols and Derivatives;Amines and Anilines;pharmacetical;Pyrans, Piperidines &Piperazines;Piperidine;Heterocyclic Compounds;Piperidines;Pyrans, Piperidines & Piperazines

After introducting the basic properties of N-BOC-4-Hydroxypiperidine, I will show you some suppliers information about this chemical on Guidechem, if you need to buy some N-BOC-4-Hydroxypiperidine, you can access to Guidechem, and contact them. I hope this information is useful for you.

Supplier one

N-BOC-4-Hydroxypiperidin(CAS NO:109384-19-2)

Updatetime:Nov 25 2013

Purity:98.00% Min. Order:10/Gram Supply Ability:560 Month/Kilogram

DetailDesc: Appearance: white or off-white crystalline powder Molecular Weight: 201.26 Density: 1.107 g/cm3 Boiling Point: 292.3 oC at 760 mmHg Melting Point: 60-65℃ Flash Point: 130.6 oC Storage Temperature: Store at -15°C Refractive index: 1.495

Tel:86-27-88660577

Address:27th FL.shuian international masion Bldg.1,Heping Ave.wuhan city

Supplier two

N-BOC-4-Hydroxypiperidin

Updatetime:Nov 25 2013

Min. Order:1/Gram Supply Ability:10 Month/Metric Ton

DetailDesc:tert-butyl 4-hydroxypiperidine-1-carboxylate

Tel:86-571-85232161

Address:6th Floor, Block C, 7th Building, Xigang Xinjie, Xihu Industrial Park, Sandun Town, Hangzhou, China.

Supplier three

N-BOC-4-Hydroxypiperidin

Updatetime:Sep 23 2013

Purity:95%min Min. Order:mg/g/Gram Supply Ability:g/kg Month/Kilogram

DetailDesc:We are a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. Those chemicals are widely used in the pharmaceutical and fine chemical industries and in research laboratories.

Tel:86-755-33239182

Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

Supplier four

N-BOC-4-Hydroxypiperidin

Updatetime:Nov 25 2013

Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

DetailDesc:1,1-Dimethylethyl4-hydroxypiperidine-1-carboxylate;1-(tert-Butoxycarbonyl)-4-hydroxypiperidine;1-(tert-Butyloxycarbonyl)piperidin-4-ol;1-Boc-4-hydroxypiperidine;1-Boc-piperidin-4-ol;1-tert-Butoxycarbonyl-4-piperidinol;1-tert-Butyloxycarbonyl-4-hydroxypiperidine;4-Hydroxy-1-(tert-...

Tel:0086-531-58773055

Address:No.59 Gongye South RD

Supplier five

N-BOC-4-Hydroxypiperidin

Updatetime:Oct 16 2013

Tel:86-21-12345678

Address:Lane No.36, Zhongke road 2195, Zhangjiang high-tech park, Pudong new area Shanghai, China

Introduction:Founded by a group of veterans from the US biopharmaceutical industry in 2010, P&T is now a leading Shanghai-based CRO company providing drug discovery and development services worldwide. With our technical expertise and excellent research facilities, we offer broad and integrated chemical synthesis (custom synthesis, library design and synthesis), medicinal chemistry (hit generation, lead opt...

Supplier six

N-BOC-4-Hydroxypiperidin

Updatetime:Nov 25 2013

Tel:86-311-89830448

Address:Room 37-2-2501, Yiyuan Dong Gang Jianshe Nan Stree

Introduction:Shijiazhuang Sdyano Fine Chemical Co., Ltd. is a company specializing in pharmaceutical intermediates, liquid crystal intermediates, PDLC LCD, OLED LCD, such as fine chemicals R & D, production and sales of integrated chemical enterprise modernization. Our company has three subsidiaries: R & D center, production base and sales. The production quantity can be done from the number of grams...

Want to learn more information about N-BOC-4-Hydroxypiperidine, you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals.

Thiophene-2-ethylamine, also known as Thiofuran, is a cyclic compound containing four carbon atoms and one sulphur atom in a ring. It is a toxic, flammable, highly reactive, colorless liquid insoluble in water (soluble in alcohol and ether) and melts at -38 C, boils at 84 C. It is used as a solvent and chemical intermediate. Its derivatives are widely used in manufacturing dyes, aroma compounds and pharmaceuticals. They are used as monomers to make condensation copolymers.

The other properties of Thiophene-2-ethylamine are:

IUPAC Name: 2-thiophen-2-ylethanamine  

Formula: C6H9NS

MOL WT: 127.20

PHYSICAL STATE: clear to yellow liquid

SOLVENT SOLUBILITY: slightly soluble

STABILITY: Stable under ordinary conditions

CAS NO. : 30433-91-1

Thiophene-2-ethylamine is an analog to furan and pyrrole where the sulfur atom is replaced by O and NH respectively. It is a toxic, flammable, and colorless liquid; insoluble in water (soluble in most organic solvents including alcohol and ether); melting at -38 C, boiling at 84 C. 

Thiophene-2-ethylamine(CAS NO:30433-91-1) is lipid-lowering drugs, platelet aggregation inhibitors, cardiovascular vasodilators, 5 - lipoxygenase inhibitors and a variety of antimicrobial drugs and other biologically active drug intermediates, mainly used for the synthesis of cardiovascular and cerebrovascular disease drugs ticlopidine hydrochloride.  As downstream drug development, the Thiophene-2-ethylamineis paid more attention to the fine chemical intermediates.

It is the simplest aromatic compound containing sulfur atom and it shares some similar chemical properties with benzene. The lone electron pairs on sulfur in the delocalized pi electron system does not exhibits the properties of thioethers but aromaticity. The sulfur atom is unreactive but the adjacent carbons are susceptible to attack by electrophiles. It is reactive toward sulfonation. 

In commercial Thiophene-2-ethylamine can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson's reagent. This compoud and its derivatives exist in petroleum or coal. It derivatives are also found in natural plant pigments. Biotin, a water-soluble B-complex vitamin, is a reduced thiophene derivative. Thiophene moiety is found in ccphalothin antiboitics. 

Thiophene-2-ethylamine is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. They are used as monomers to make condensation copolymers. Organic conductive polymers are responsible for the important materials science for the application of polymer electro luminescence.

Thiophene-2-ethylamine is used as an intermediate to manufacture pharmaceuticals such as antiplatelet drug (Clopidogrel, Ticlopidine) used to lessen the chance of heart attack or stroke.

Want to learn more information about Thiophene-2-ethylamine,you can access the guidechem.com. Guidechem.com is just a place for you to look for some chemicals. Guidechem provide the most convenient conditions for the international buyers and let these leads benefit all the business people. Guidechem chemical B2B network provides information on china and global chemical market quotation and relative chemical Information. Guidechem Chemical Network providing the most complete information of the chemical industry.

Hexamethyldisilazane is an organosilicon compound with the molecular formula [(CH3)3Si]2NH. It is also named HMDS. The molecule is a derivative of ammonia with trimethylsilyl groups in place of two hydrogen atoms. This colorless liquid is a reagent and a precursor to bases that are popular in organic synthesis and organometallic chemistry. The Molecular Weight is 161.39, EINECS is 213-668-5, and the CAS NO is 999-97-3.

Usage 

One of the uses of Hexamethyldisilazane is as a reagent in condensation reactions of heterocyclic compounds such as in the microwave synthesis of a derivative of xanthine.HMDS can be used to convert alcohols into trimethylsilyl ethers. It can be used to silylate laboratory glassware and make it hydrophobic, or automobile glass, just as Rain-X does. In gas chromatography, it can be used to silylate OH groups of organic compounds to increase volatility, this way enabling GC-analysis of chemicals that are otherwise non-volatile.

In photolithography, Hexamethyldisilazane(CAS NO:999-97-3) is often used as an adhesion promoter for photoresist. Best results are obtained by applying this compoud from the gas phase on heated substrates. In electron microscopy, it can be used as an alternative to critical point drying during sample preparation.In pyrolysis-gas chromatography-mass spectrometry, it is added to the analyte to create sylilated diagnostic products during pyrolysis, in order to enhance detectability of compounds with polar functional groups.

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a cool, dry place. Keep container closed when not in use. Store in a tightly closed container. Flammables-area.

Handling

Wash thoroughly after handling Hexamethyldisilazane. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Take precautionary measures against static discharges. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Use only in a chemical fume hood. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Clean up spills immediately, using the appropriate protective equipment. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition.

Protection about Hexamethyldisilazane

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators about Hexamethyldisilazane

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

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