Cyclosporin A is an immunosuppressive drug. Since 1983 is used as prophylaxis in patients after transplantation what increases the post-transplantation survival rate and improves patient’s quality of life. Although the drug was discovered in 1970 and used to treat psoriasis in 1973, it is more commonly associated with transplantology. 

Cyclosporin A(CAS NO:59865-13-3) inhibits humoral and cellular components of inflammatory response. That is why it is also used not only in the treatment of chronic inflammatory and autoimmune diseases such as rheumatoid arthritis or psoriasis, but also in severe atopic eczema which is resistant to other treatment.

Prophylaxis of organ rejection in kidney, liver, and heart allogeneic transplants in conjunction with adrenal corticosteroid therapy; Sandimmune may be used in the treatment of chronic rejection in patients previously treated with other immunosuppressive agents; increase tear production in patients whose tear production is presumed to be suppressed because of ocular inflammation associated with keratoconjunctivitis sicca .

Treatment of severe, active RA where disease is not adequately responsive to methotrexate; treatment of adult, nonimmunocompromised patients with severe, recalcitrant, plaque psoriasis who have failed to respond to a least one systemic therapy or in patients for whom other systemic therapies are contraindicated, or cannot be tolerated.

Cyclosporin A(CAS NO:59865-13-3) and FK506 (tacrolimus) are potent immunosuppressive drugs widely used in reducing the incidence and severity of allograft rejection after organ transplantation. Owing to their capacity to antagonize calcineurin activity and hence calcium-dependent T-cell activation, both drugs were thought to have identical cellular and molecular effects, despite differences in their structure. 

This notion was challenged by both clinical and experimental evidence clearly showing that Cyclosporin A and FK506 immunosuppressive effects are not identical, and that FK506 affects Cyclosporin A-sensitive and Cyclosporin A-insensitive T-cell activation pathways. Here we discuss recent findings, including our own, which highlight differences in efficacy and mechanisms between Cyclosporin A and FK506.

Treatment may be associated with a number of potentially serious adverse drug reactions. They can include gingival hyperplasia, convulsions, peptic ulcers, pancreatitis, fever, vomiting, diarrhea, confusion, hypercholesterolemia, dyspnea, numbness and tingling particularly of the lips, pruritus, high blood pressure, potassium retention possibly leading to hyperkalemia, kidney and liver dysfunction (nephrotoxicity and hepatotoxicity), burning sensations at finger tips and an increased vulnerability to opportunistic fungal and viral infections.

In short, it is nephrotoxic, neurotoxic, causes hypertension (due to renal vasoconstriction and increased sodium reabsorption), increases the risk of squamous cell carcinoma and infections. It also causes gingival hypertrophy and hirsutism which is not seen with tacrolimus (another calcineurin inhibitor).

An alternate form of the drug, cyclosporin G has been found to be much less nephrotoxic than the standard cyclosporin A. Cyclosporin G (molecular mass 1217) differs from cyclosporin A in the amino acid 2 position, where an L-norvaline replaces the α-aminobutyric acid.

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Ferrous fumarate or iron(II) fumarate is the salt of fumaric acid. Molecular mass of this compound is C4H2FeO4, and it has a molar mass of 169.9. Following is the structure of ferrous fumarate. Ferrous fumarate is a reddish orange powder. It is a good iron supplement. It has 32.87% of iron in one molecule. This is used to treat iron deficiency anemia. However, if it is taken in large amounts, side effects like drowsiness, severe nausea or stomach pain, vomiting, bloody diarrhea can result.

If you need large number of Ferrous fumarate(CAS NO:141-01-5), you must read this article patiently. I will show you some suppliers information about this chemical on Guidechem, if you need to buy some Ferrous fumarate, you can access to Guidechem, and contact them. I hope this information is useful for you. Now here are the information.

1.Shanghai Dell Chemical Co.Ltd

Ferrous fumarate(CAS NO:141-01-5)

Updatetime:Dec 12 2013

Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.

Tel:86-21-51950635

Address:Nianjiabang Rd, Pudong, Shanghai

2.Wuhan Haizheng Industry & Trade Development Co. Ltd

Updatetime:Dec 10 2013

Purity:99% Min. Order:1/Gram Supply Ability:300 Month/Kilogram

DetailDesc: Name : Ferrous fumarate CAS: 141-01-5 Synonyms: FERROUS FUMARATE FERROUS FUMERATE IRON(+2)FUMARATE iron FUMARATE IRON(II) FUMARATE 2-Butenedioicacid(E)-,iron(2+)salt(1:1) cpiron erco-fer ercoferro feostat feroton ferrofume ferronat ferrone ferrotemp Ferroustrans-butenedi.

Tel:86-27-88660577

Address:27th FL.shuian international masion Bldg.1,Heping Ave.wuhan city.

3.JAI RADHE SALES  Country/Region：India

Updatetime:Aug 07 2013

DetailDesc: EC NO:205-447-7 MF:C4H2FeO4 Synonyms:Ferrous Fumarate;Ironfumarate;

Address:309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA.

4.Weifang Sunwin Chemicals Co., Ltd

Ferrous fumarate

Updatetime:Jul 10 2013

FOB Price:1 USD/Kilogram Purity:97% Min. Order:1/Kilogram Supply Ability:1000 

DetailDesc: Ferrous Fumarate [CAS RN]: 141-01-5 [Product Code]: SFE02 [Structure]: [Molecular Formula]: C 4 H 2 FeO 4 [Molecular Weight]: 169.9024 [Physical Properties]: Red-orange or red -brown powder,odorless, tasteless,slightly soluble in water ,slightly soluble in alcohol .

Tel:86-21-50463411

Address:No, 1, Jilong Road, Room 922, Tomson International Trade, Waigaoqiao Free Zone, Shanghai, China

5.Jiaoda Rising Weinan Chemical Industry Co., Ltd.

Ferrous fumarate

Updatetime:Jan 31 2013

Introduction: Profile: Jiaoda Rising Weinan Chemical Industry Co., Ltd. manufactures chemicals and intermediates. Our products are xylene, heavy benzene, dl-malic acid, piperazine, triethyl enediamine and fumaric acid. Our fumaric acid is used as a pharmaceutical intermediate and optical bleaching agent. Our piperazine is used in curing agents, preservatives, antioxidants, and surfactants.

Tel:+86-(913)-219-5485, 209-6159

Address:Liangshuiqiao, Dongguan, Weinan, Shanxi 714000.

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Methyl acetoacetate is a kind of colorless liquid, we also call it Acetoacetic acid methyl ester or Butanoic acid, 3-oxo-, methyl ester. The Molecular Formula is C5H8O3, Molecular Weight is 116.12, and CAS Registry Number is 105-45-3.

Methyl acetoacetate is stable under normal temperatures and pressures. We should store Methyl acetoacetate in a cool, dry place, and keep the container closed when not in use. Methyl acetoacetate (MAA) is a starting material for the syntheses of alpha-substituted aceto- acetic esters and cyclic compounds, e.g. pyrazole, pyrimidine and coumarin derivatives.

After introducting the basic properties of Methyl acetoacetate(CAS NO:105-45-3), I will show you some suppliers information about this chemical on Guidechem. If you need to buy this chemical, you can access to Guidechem, and contact them, I hope this information is useful for you.

Company one : Shanghai Dell Chemical Co.Ltd

Updatetime:Dec 10 2013

Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.

Tel:86-21-51950635

Address:Nianjiabang Rd, Pudong, Shanghai

Company two :Jinan Haohua Industry Co., Ltd.

Updatetime:Dec 10 2013

Purity:99 Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

DetailDesc:Acetoaceticacid, methyl ester (6CI,8CI); 3-Oxobutanoic acid methyl ester; 3-Oxobutyricacid methyl ester; Acetoacetate methyl ester; Methyl 3-oxobutanoate; Methyl3-oxobutyrate; Methyl acetoacetate; Methyl acetylacetate

Tel:0086-531-58773055

Address:No.59 Gongye South RD

Company three : Nanjing Chemlin Chemical Co., Ltd.

Updatetime:Dec 09 2013

Purity:97.00%

DetailDesc:intermediates, drug discovery

Tel:86-25-83697070

Address:Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China

Company four : Finetech Industry Limited

Methyl acetoacetate

Updatetime:Oct 06 2013

Introduction:Finetech Industry Limited specializes in the development, manufacture and marketing of Fine organic Compounds & Intermediates for the Pharmaceutical Industry. Tel:+86-(27)-87772287

Address:Guanggu Road, Wuhan, Hubei 430073

Company five : Conier Chem & Pharma Co.,Ltd.

Methyl acetoacetate

Updatetime:Aug 26 2013

Tel:+86-(23)-62922305

Address:24 South Section 1, Yihuan Road, Chengdu, Sichuan 610065,

Introduction: Conier Chem & Pharma Co.,Ltd. offers Pharmaceutical Intermediates, Fine Chemicals and APIs. We supply darifenacin, venlafaxine HCl, nebivolol, qQuetiapine, methoxyindole, 2-Methyl-5-pyrimidinemethanol and 4-phenoxypyridine. We develop comprehensive service in the field of chemical and pharmaceutical. 

Company six : Goly Chemical Co., Ltd.

Methyl acetoacetate

Updatetime:Jan 16 2013

Tel:+86-(632)-6163187

Address:Room No.6.Building21 LongXingBeiLi,ShiZhong, ZaoZhua, ShanDong 277102,

Introduction:Goly Chemical Co., Ltd. specializes in Active Pharmaceutical Ingredients, Intermediates, Specialty Chemicals, and Water Treatment Agents & Food Additives. We focus on the Special Chemicals and Fine Chemicals such as Active Pharmaceutical Ingredients Organic Intermediates Inorganic Compound Amino Acid Series Fluoro-Compound.

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During the 1960s and 1970s there were several studies of the dietary requirement for sulfur amino acids, which employed ranges of intakes of D-Methionine (with or without cyteine) from below to above the estimated requirement. 

The highest intakes given to adults were almost three times the current estimates of the requirement; derived from studies of graded intake levels in volunteers, but no adverse effects were reported; Nutritional studies of sulfur amino acids in healthy and malnourished children have not employed such large excesses over requirement, so they might not be expected to show any adverse effects.

Previous reviews of D-Methionine(CAS NO:348-67-4) toxicity have relied largely on data derived from animals and have led to the belief that this chemical is the most toxic amino acid ; In humans, however, despite the use of D-Methionine to detoxify acetaminophen (paracetamol) and its role as a precursor of homocyteine, an indicator of cardiovascular risk, there appear to have been no systematic studies with toxicity or adverse effects as the primary focus. 

The aim of this paper is, therefore, to examine the literature for evidence that might enable the safety of methionine in humans to be derived; For this purpose, literature searches were performed including journals from the fields of nutrition and metabolism (including amino acid requirements), physiology, pharmacology, psychology, and clinical medicine.

D-Methionine(CAS NO:348-67-4) has also been given to induce acidosis. In a study to investigate whether the acidosis induced by the metabolism of an oral dose of 11.3 g of D-Methionine would modify ketosis during starvation or ketogenic dieting, the fall in blood pH was similar to that produced by an equivalent dose of ammonium chloride;This could be detrimental to the subjects if continued for extended periods, as metabolic acidosis has been shown to result in an inhibition of muscle protein synthesis in animals . 

Moreover, in human volunteers, acidosis resulted in negative nitrogen balance and decreased synthesis of muscle protein and serum albumin which could be detrimental to body protein homeostasis if continued. The acidosis induced by D-Methionine could be the rationale for the prevention of recurrent urinary tract infections by L-Methionine; In another clinical study, D-Methionine (5 or 10 g/d) was given to patients as a treatment for rheumatoid polyarthritis; No serious adverse effects were reported, although nausea, vomiting, constipation, and halitosis were frequent.

D-Methionine is an indispensable amino acid for humans, but there is evidence that if given in excess. It can interfere with the utilization of nitrogen from dispensable amino acids. In studies of nitrogen balance in subjects receiving low-protein diets, nitrogen balance was improved in subjects receiving low protein plus urea or low protein plus glycine, but not with diets containing low protein plus D-Methionine or low protein plus both D-Methionine and urea; Also, the urinary excretion of 5-L-oxoproline, a marker of glycine availability, was significantly lower when the diets contained low protein plus urea or low protein plus urea and D-Methionine. 

There was a significant correlation between the excretion of 5-L-oxoproline and excretion of sulfate. The interpretation was that glycine was consumed to detoxify the excess D-Methionine, with the result that the availability of glycine for other metabolic processes became limiting. 

Azamethiphos is a veteran organophosphates used almost exclusively for the off-animal control of houseflies and nuisance flies aas well as crawling insects in livestock operations: stables, dairy premises, piggeries, poultry houses, etc.

Azamethiphos is highly effective against susceptible houseflies and it kills them very quickly. It acts mostly by oral ingestion. This means that the contact (or tarsal) effect is usually insufficient against bloodsucking flies.Azamethiphos(CAS NO:35575-96-3) was previously used as a pesticidal spray for control of flies and cockroaches in warehouses and other buildings, but the authorisation was withdrawn by Commission Regulation Interestingly.

Azamethiphos as a bait shows an excellent efficacy against certain housefly populations resistant to other organophosphates and carbamates. However, there are also housefly strains that are specifically resistant to azamethiphos, apparently because they simply avoid the sugar in the scatter baits or added to the concentrates to increase its attractiveness for houseflies.

Azamethiphos (CAS NO:35575-96-3)also has efficacy against some poultry mites, cockroaches and other crawling pests, but it is usually insufficient to control serious infestations. Azamethiphos is also used as a lousicide in fish farms, especially against salmon lice.

However, resistance of houseflies and other pests to all organophosphates, including azamethiphos is widespread. As a consequence, products with this active ingredient may not achieve the expected efficacy in many places. The same applies to all other organophosphates. This is also a reason for their progressive replacement with newer active ingredients with a different mode of action.

Notice. As a general rule this site does not provide information about off-label uses of antiparasitic active ingredients. In most countries veterinary doctors can prescribe a veterinary medicine for indications that are not included in its label. This is often the case for minor speciesand orphan diseases that are not investigated by pharmaceutical companies for whatever reasons. 

An analytical method for the determination of residues of azamethiphos in salmon tissues based on HPLC with UV detection and described in the ISO 78/2 format was available. The method was of appropriate specificity and it had been shown that residues of dichlorvos, trichlofon, and the Azamethiphos metabolite 2-amino-3-hydroxy-5-chloropyridine did not interfere in the assay. 

The limit of quantification was 42 µg/kg for salmon muscle and for salmon skin. Validation data for muscle with skin in natural proportions were not provided and data for accuracy and precision were provided at only 2 concentrations. 

Azamethiphos is “No MRL required” therefore an analytical method for monitoring purposes is not required. No analytical method for the determination of residues of Azamethiphos in other fin fish was provided. Considering that in the previous evaluation it was concluded that no MRL was required for Salmonidae no analytical method was required for other fin fish. 

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Basic properties:

IUPAC Name: 2-aminopropan-1-ol   

Physical state: viscose liquid

Boiling range: 173-176 C (760mmHg )

Flash Point: 83.9 C

Density: 0.9650g/cm3 

Molecular formula: C3H9NO2 

Molecular weight: 75.11 C 

Storage temp: 2-8 C

Sensitive: Hygroscopic 

Enthalpy of Vaporization: 47.83 kJ/mol 

Vapour Pressure: 0.373 mmHg at 25CAS NO: 2749-11-3

Appearance: clear and colorless

After introducting the basic properties of (S)-(+)-2-Amino-1-propanol, I will show you some suppliers information about this chemical on Guidechem, if you need to buy some (S)-(+)-2-Amino-1-propanol, you can access to Guidechem, and contact them. I hope this information is useful for you.

Supply information:

Shanghai Pengteng Fine Chemical Co., Ltd.

Updatetime:Oct 17 2013

DetailDesc:Our company keeps the business tenet of “people first and customer esteemed” and the service principle of “superior quality, reasonable price, good faith”. We insist on the principle of win-win cooperation and would like to create brilliant future hand in hand with you!

Tel:86-15262230-560

Address:No.9, Haikou Road, Huai'an Industiral Park, Jiangsu Province, China

Hui Chem Company Limited

Updatetime:Dec 09 2013

Purity:98% Min. Order:1/Gram Supply Ability:10 Month/Kilogram

DetailDesc:We could receive custom synthesis according to your requirements from lab scale to commercial scale

Tel:86-21-60542966

Address:Lane 299 Bisheng Rd,Pudong District

Shenyang Ideal Chemical Product Co.,Ltd

(S)-(+)-2-Amino-1-propanol

Updatetime:Dec 09 2013

DetailDesc: Synonyms: L-Alaninol; Aminopropanol,95%; H-Ala-ol; DL-Alaninol Classification: Pharmaceutical Intermediates EINECS: 220-388-7 Molecular Formula: C3H9NO Melting Point: -2 C Boiling Point: 173-176 C Stability: Water Solubility: Refractive index: 1.4488-1.4508 Flash Point: 62 C Purity: 99 Appearance: Colorless thick liquid HazardClass: 8 Brand Name:

Tel:86-24-31689845

Address::(1-7-4),18-A South No. 2 Road ,Heping District

Hope Pharmaceutical Co., Ltd.

(S)-(+)-2-Amino-1-propanol

Updatetime:Oct 16 2013

Introduction:Founded by a group of veterans from the US biopharmaceutical industry in 2010, P&T is now a leading Shanghai-based CRO company providing drug discovery and development services worldwide. With our technical expertise and excellent research facilities, we offer broad and integrated chemical synthesis, medicinal chemistry.

Tel:86-21-12345678

Address:Lane No.36, Zhongke road 2195, Zhangjiang high-tech park, Pudong new area Shanghai, China

SHANGHAI JIEKE BIOTECHNOLOGY CO.,LTD

(S)-(+)-2-Amino-1-propanol

Updatetime:Dec 09 2013

Purity:99 Min. Order:1000/Gram Supply Ability:10000 Month/Kilogram

DetailDesc: L - amino propyl alcohol CAS number: 2749-11-3 Usage: useful for pharmaceutical intermediates Outer view colorless thick liquid Pure degree was 99.0% Water runs 0.5% .

Tel:86-319-7265503

Address:NO.1008 Qigangroad,FengXianZone,ShangHai,China

Shanghai Hongbang Medical Technology CO., Ltd

(S)-(+)-2-Amino-1-propanol

Updatetime:Dec 09 2013

FOB Price:0 USD/Kilogram Purity:99.0%min Min. Order:1/Kilogram Supply Ability:50 Year/Metric Ton

DetailDesc: Name: L-Alaninol Synonyms: (S)-(+)-2-Amino-1-propanol; (+)-2-Aminopropan-1-ol; L-(+)-Alaninol Identification : Molecular Formula: C3H9NO Molecular Weight: 75.11 CAS Registry Number: 2749-11-3 EINECS: 220-388-7 ; Properties : Density: 0.965 Boiling point: 173-176 C

Tel:86-136-71516988

Address:Yongde Road369, Minhang District, Shanghai City

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D(+)-Malic acid is a kind of white crystals or white crystalline powder, soluble in water, alcohol and other organic solvent. Its aqueous solution is acidic. It is an important four-carbon atoms chiral pool. It is mainly used in many fields including chiral pharmaceuticals, chiral additives and chiral auxiliaries. It is used as chiral pool of chiral synthesis in pharmaceutical and food industries. As an optically active organic acid, it is insubstitutable in asymmetry synthesis of some chiral compounds.

D(+)-Malic acid(CAS NO:636-61-3) was first isolated from apple juice by Carl Wilhelm Scheele in 1785. Antoine Lavoisier in 1787 proposed the name acide malique which is derived from the Latin word for apple,D(+)-Malic acid contributes to the sourness of green apples. 

It is present in grapes and in most wines with concentrations sometimes as high as 5 g/L. It confers a tart taste to wine, although the amount decreases with increasing fruit ripeness. The process of malolactic fermentation converts this compound to much milder lactic acid. It occurs naturally in all fruits and many vegetables, and is generated in fruit metabolism.

D(+)-Malic acid(CAS NO:636-61-3), when added to food products, is denoted by E number E296. It is the source of extreme tartness in USA-produced confectionery, the so-called extreme candy. It is also used with or in place of the less sour citric acid in sour sweets. These sweets are sometimes labeled with a warning stating that excessive consumption can cause irritation of the mouth. It is approved for use as a food additive in the EU,USA and Australia and New Zealand

L-Malic acid is the naturally occurring form, whereas a mixture of L- and D-malic acid is produced synthetically. Malate plays an important role in biochemistry. In the C4 carbon fixation process, malate is a source of CO2 in the Calvin cycle. In the citric acid cycle, (S)-malate is an intermediate, formed by the addition of an -OH group on the si face of fumarate. It can also be formed from pyruvate via anaplerotic reactions.

D(+)-Malic acid is also synthesized by the carboxylation of phosphoenolpyruvate in the guard cells of plant leaves.D(+)-Malic acid, as a double anion, often accompanies potassium cations during the uptake of solutes into the guard cells in order to maintain electrical balance in the cell. The accumulation of these solutes within the guard cell decreases the solute potential, allowing water to enter the cell and promote aperture of the stomata.

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Ranolazine is a medication that belongs to the drug class known as cardiovascular agents. Ranexa is prescribed for the treatment of chronic angina. Common side effects of Ranexa include dizziness, nausea, constipation, headache, swelling in hands, ankles, or feet, slow, fast, or irregular heartbeats, tremors, blood in the urine and shortness of breath.

Ranolazine(CAS NO: 95635-55-5 )is indicated for the treatment of chronic angina; it may be used in combination with beta blockers, nitrates, calcium channel blockers, antiplatelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers. It has been shown to decrease angina episodes in individuals with coronary artery disease on maximal doses of amlodipine.

In addition, it has been shown to both decrease angina episodes and increase exercise tolerance in individuals taking concomitant atenolol, amlodipine, or diltiazem.

Unlike other antianginal medications, such as nitrates and beta blockers, ranolazine(CAS NO:95635-55-5) does not significantly alter either the heart rate or blood pressure, so it is of particular use in individuals with angina who are not responsive to maximal tolerated doses of other antianginal medications.

It would seem from the mechanism of action--that ranolazine may be of benefit in individuals with non-ST-elevation acute coronary syndromes (ACS) and acute myocardial infarction (heart attack). However the recently completed Merlin/TIMI-36 trial showed no benefit in this population.

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

A total of 2,018 patients with chronic angina were treated with ranolazine in controlled clinical trials. Of the patients treated with Ranolazine, 1,026 were enrolled in three double-blind, placebocontrolled, randomized studies (CARISA, ERICA, MARISA) of up to 12 weeks' duration. In addition, upon study completion, 1,251 patients received treatment with Ranolazine in open-label, long-term studies; 1,227 patients were exposed to RANEXA for more than 1 year, 613 patients for more than 2 years, 531 patients for more than 3 years, and 326 patients for more than 4 years.

In controlled clinical trials of angina patients, the most frequently reported treatment-emergent adverse reactions ( > 4% and more common on RANEXA than on placebo) were dizziness (6.2%), headache (5.5%), constipation (4.5%), and nausea (4.4%). Dizziness may be doserelated. In open-label, long-term treatment studies, a similar adverse reaction profile was observed.

At recommended doses, about 6% of patients discontinued treatment with Ranolazine because of an adverse event in controlled studies in angina patients compared to about 3% on placebo. The most common adverse events that led to discontinuation more frequently on Ranolazine than placebo were dizziness (1.3% versus 0.1%), nausea (1% versus 0%), asthenia, constipation, and headache (each about 0.5% versus 0%). Doses above 1000 mg twice daily are poorly tolerated.

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Properties of 4-Nitro-3-(trifluoromethyl)aniline

Product Name: 4-Nitro-3-(trifluoromethyl)aniline

Molecular Formula: C7H5F3N2O2

Molecular Weight: 206.12g/mol

Mol File: 393-11-3.mol 

EINECS: 206-884-6

Melting Point: 125-129 C(lit.)

Boiling point: 326.4 C at 760 mmHg

Flash Point: 151.2 C 

Density: 1.503 g/cm3 

CAS NO.: 393-11-3

MSDS of 4-Nitro-3-(trifluoromethyl)aniline

1.First Aid Measures

Ingestion:Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin: Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

2.Hazards Identification

Ingestion: Ingest 4-Nitro-3-(trifluoromethyl)aniline(CAS NO:393-11-3) may cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Inhalation: It May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin: May cause skin irritation.

Eyes: May cause eye irritation.

UN (DOT): 2811

EC Safety Phrase: S 26 36/37/39

EC Risk Phrase: R 20/21/22 36/37/38

3.Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

4.Fire Fighting Measures

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

5.Accidental Release Measures

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

6.Handling and Storage

Handling:

Wash thoroughly after handling 4-Nitro-3-(trifluoromethyl)aniline. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid 4-Nitro-3-(trifluoromethyl)aniline contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation 4-Nitro-3-(trifluoromethyl)aniline.

Storage:

Store 4-Nitro-3-(trifluoromethyl)anilinein a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Basic chemical and physical information

Product name: 2-chloro-5-iodopyridine

Product Number Brand: 498181

Molecular formula: C5H3ClIN 

Molecular Weight: 239.44g/mol 

Surface Tension: 51.7 dyne/cm  

Density: 2.052 g/cm3  

Flash Point: 106.9 C 

Melting point: 95-98 C(lit.)

Water Solubility: insoluble 

Sensitive: Light Sensitive

Index of Refraction: 1.642  

Molar Refractivity: 42.14 cm3  

Molar Volume: 116.6 cm3  

CAS No. : 69045-79-0

Enthalpy of Vaporization: 47.07 kJ/mol  

Boiling Point: 253.2 C at 760 mmHg  

Vapour Pressure: 0.0295 mmHg at 25 C

Identified uses : Laboratory chemicals, Manufacture of substances

After introducting the basic properties of 2-Chloro-5-iodopyridine, I will show you some suppliers information about this chemical on Guidechem, if you need to buy some 2-Chloro-5-iodopyridine, you can access to Guidechem, and contact them. I hope this information is useful for you.

Supply information one

2-Chloro-5-iodopyridine

Updatetime:Dec 04 2013

Purity:NLT99% Min. Order:1/Kilogram Supply Ability:100 Year/Metric Ton

DetailDesc:Shanghai Dell Chemical Co.Ltd. is specialized in trading and developing active pharmaceutical ingredients, intermediates, API, and custom synthesis according to client’s requirements.

Tel:86-21-51950635

Address:Nianjiabang Rd, Pudong, Shanghai

Supply information two

2-Chloro-5-iodopyridine

Updatetime:Sep 23 2013

Purity:95%+ Min. Order:mg/g/Gram Supply Ability:kg/T Month/Kilogram

DetailDesc:We are a leading global supplier and manufacturer of chiral chemicals, amino acids, aromatic and pyridine halogens, natural extracts and pharmaceutical raw materials. Those chemicals are widely used in the pharmaceutical and fine chemical industries and in research laboratories.

Tel:86-755-33239182

Address:Huiji302 Hutingju Sanwei Xixiang SHENZHEN 518126, China

Supply information three

2-Chloro-5-iodopyridine

Updatetime:Oct 17 2013

DetailDesc:Our company keeps the business tenet of “people first and customer esteemed” and the service principle of “superior quality, reasonable price, good faith”. We insist on the principle of win-win cooperation and would like to create brilliant future hand in hand with you!

Tel:86-1383-5989052

Address:No.9, Haikou Road, Huai'an Industiral Park, Jiangsu Province, China

Supply information four

2-Chloro-5-iodopyridine

Updatetime:Dec 04 2013

Min. Order:1/Kilogram

DetailDesc: Classification: Pharmaceutical Intermediates Molecular Formula: C5H3ClIN 

Melting Point: 96-99 C Boiling Point: 253.2 C at 760 mmHg Water Solubility: insoluble Flash Point: 106.9 C Purity: 99% Appearance: off-white to yellow-beige crystalline powder HazardClass: IRRITANT Packaging & Delivery Packaging Detail: as requeste...

Tel:86-311-80955068

Address:No 98 Gongnong Street,Shijiazhuang Hebei,China

Supply information five

2-Chloro-5-iodopyridine

Updatetime:Dec 03 2013

DetailDesc: Classification: Pharmaceutical Intermediates Molecular Formula: C5H3ClIN Melting Point: 96-99℃ Boiling Point: 253.2 C at 760 mmHg Water Solubility: insoluble Flash Point: 106.9 C Purity: 99% Appearance: off-white to yellow-beige crystalline powder HazardClass: IRRITANT Packaging & Delivery Packaging Detail: as requested Delivery Detail: Detailed Description off-white to yellow-beig

Tel:86-24-31689845

Address::(1-7-4),18-A South No. 2 Road ,Heping District

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