What can Florfenicol be used for ?
Florfenicol is a kind of white crystalline powders, it has been marketed by Schering-Plough Animal Health under the trade name Nuflor, a fluorinated synthetic analog of thiamphenicol with Molecular Formula:C12H14Cl2FNO4S and Molecular Weight:358.21. Florfenicol is stable at normal temperatures and pressures, insoluble in water.
Since its launch in 1996, Florfenicol(CAS NO:73231-34-2) has gained several additional approvals. It is now prescribed for not only bovine respiratory disease (BRD) but also foot rot. For BRD it can be used as a hospital treatment or for high-risk cattle on arrival at the feedyard. If you'd like to learn more about Florfenicol, we have a full menu of topics for you to choose from.
In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus, for treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
The use of florfenicol(CAS NO:73231-34-2) in horses, and likely in other equids, typically causes diarrhea. This has been anecdotally reported to progress to lethal cases of acute colitis. Therefore, use of this antimicrobial in the equine patient should be limited to cases in which other, safer, options are not available.
Florfenicol, a veterinary fluorinated analog of thiamphenicol, is approved for treatment of bovine respiratory pathogens in the United States. However, florfenicol resistance has recently emerged among veterinary Escherichia coli isolates incriminated in bovine diarrhea.
Florfenicol is a fluorinated structural analog of thiamphenicol and chloramphenicol approved by the Food and Drug Administration (FDA) in 1996 for treatment of bovine respiratory pathogens such as Pasteurella spp. However, it is not currently approved for treatment of E. coli-related cattle enteric diseases in the United States. Additionally, there are no approved NCCLS breakpoints for E. coli currently available; however, the resistance breakpoint for bovine respiratory pathogens.
Florfenicol is not approved for human use; however, it is related to chloramphenicol and can select for cross-resistance among bacterial pathogens. Florfenicol has been shown to have a spectrum of activity similar to that of chloramphenicol, except that it is active at lower concentrations than chloramphenicol against a variety of clinical bacterial isolates, including chloramphenicol-resistant bacteria. Florfenicol's mechanism of action is directed at disrupting bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome and is generally considered to be bacteriostatic.
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