What are the usags of Thiophene-2-ethylamine?
Thiophene-2-ethylamine, also known as Thiofuran, is a cyclic compound containing four carbon atoms and one sulphur atom in a ring. It is a toxic, flammable, highly reactive, colorless liquid insoluble in water (soluble in alcohol and ether) and melts at -38 C, boils at 84 C. It is used as a solvent and chemical intermediate. Its derivatives are widely used in manufacturing dyes, aroma compounds and pharmaceuticals. They are used as monomers to make condensation copolymers.
The other properties of Thiophene-2-ethylamine are:
IUPAC Name: 2-thiophen-2-ylethanamine
Formula: C6H9NS
MOL WT: 127.20
PHYSICAL STATE: clear to yellow liquid
SOLVENT SOLUBILITY: slightly soluble
STABILITY: Stable under ordinary conditions
CAS NO. : 30433-91-1
Thiophene-2-ethylamine is an analog to furan and pyrrole where the sulfur atom is replaced by O and NH respectively. It is a toxic, flammable, and colorless liquid; insoluble in water (soluble in most organic solvents including alcohol and ether); melting at -38 C, boiling at 84 C.
Thiophene-2-ethylamine(CAS NO:30433-91-1) is lipid-lowering drugs, platelet aggregation inhibitors, cardiovascular vasodilators, 5 - lipoxygenase inhibitors and a variety of antimicrobial drugs and other biologically active drug intermediates, mainly used for the synthesis of cardiovascular and cerebrovascular disease drugs ticlopidine hydrochloride. As downstream drug development, the Thiophene-2-ethylamineis paid more attention to the fine chemical intermediates.
It is the simplest aromatic compound containing sulfur atom and it shares some similar chemical properties with benzene. The lone electron pairs on sulfur in the delocalized pi electron system does not exhibits the properties of thioethers but aromaticity. The sulfur atom is unreactive but the adjacent carbons are susceptible to attack by electrophiles. It is reactive toward sulfonation.
In commercial Thiophene-2-ethylamine can be prepared by the reaction of butane and sulfur. Thiophenes are also prepared by the reaction of diketones with Lawesson's reagent. This compoud and its derivatives exist in petroleum or coal. It derivatives are also found in natural plant pigments. Biotin, a water-soluble B-complex vitamin, is a reduced thiophene derivative. Thiophene moiety is found in ccphalothin antiboitics.
Thiophene-2-ethylamine is used as a solvent and chemical intermediate. Its derivatives are used in manufacturing dyes, aroma compounds and pharmaceuticals. They are used as monomers to make condensation copolymers. Organic conductive polymers are responsible for the important materials science for the application of polymer electro luminescence.
Thiophene-2-ethylamine is used as an intermediate to manufacture pharmaceuticals such as antiplatelet drug (Clopidogrel, Ticlopidine) used to lessen the chance of heart attack or stroke.
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