Summary information about Ranolazine
Ranolazine is a medication that belongs to the drug class known as cardiovascular agents. Ranolazine is used alone or with other medications to treat ongoing angina (chest pain or pressure that is felt when the heart does not get enough oxygen).It works by improving blood flow to help the heart work more efficiently. It is used to treat chronic angina (chest pain). But it is not for use during an acute (emergency) attack of angina. Ranolazine(CAS NO:95635-55-5) may also be used for purposes not listed in this medication guide.
On 24 April 2008, the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) adopted a positive opinion, recommending to grant a marketing authorisation for the medicinal product Latixa, 375-mg, 500-mg and 750-mg, prolonged-release tablets intended for treatment of patients with stable angina pectoris. The applicant for this medicinal product is CV Therapeutics Europe Limited.
The Food and Drug Administration has approved a new, first-line indication for ranolazine for the treatment of chronic angina. The new labeling also provides information showing ranolazine(CAS NO:95635-55-5)reduced arrhythmias, including ventricular arrhythmias, new onset atrial fibrillation and a potentially dangerous slow heartbeat known as bradycardia in patients with coronary artery disease.
A total of 2,018 patients with chronic angina were treated with ranolazine in controlled clinical trials. Of the patients treated with Ranolazine, 1,026 were enrolled in three double-blind, placebocontrolled, randomized studies (CARISA, ERICA, MARISA) of up to 12 weeks' duration. In addition, upon study completion, 1,251 patients received treatment with Ranolazine in open-label, long-term studies; 1,227 patients were exposed to RANEXA for more than 1 year, 613 patients for more than 2 years, 531 patients for more than 3 years, and 326 patients for more than 4 years.
Earlier, ranolazine increasing QT interval (about 2 to 6 ms) was of concern, which has a theoretical risk of causing arrhythmia. Findings of MERLIN TIMI 36 should mitigate this concern. However, studies specifically designed to evaluate the potential role of ranolazine as an antiarrhythmic agent are warranted.
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1.Wuhan Fortuna Chemical Co., Ltd.
Ranolazine
Updatetime:Jan 09 2014
Purity:99% Min. Order:1/5/25/Kilogram
Tel:0086-27-59207850
Address:A2705,Dong Yi Shi Qu,129# XinHua Road
2.Capot Chemical Co., Ltd.
Ranolazine
Updatetime:Jan 09 2014
Purity:98% Min. Order:1/Kilogram Supply Ability:up to kgs Month/Kilogram
DetailDesc:427.54,C24H33N3O4
Tel:86-571-85586718
Address:Joinhands Science Park, No.4028,Nanhuan Road
3.AFINE CHEMICALS LIMITED
Ranolazine
Updatetime:Jan 07 2014
Min. Order:1/Gram Supply Ability:10 Month/Metric Ton
DetailDesc:Ranolazine 95635-55-5
Tel:86-571-85232161
Address:6th Floor, Block C, 7th Building, Xigang Xinjie, Xihu Industrial Park, Sandun Town, Hangzhou, China
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