Analysis what is Azamethiphos
Azamethiphos is a veteran organophosphates used almost exclusively for the off-animal control of houseflies and nuisance flies aas well as crawling insects in livestock operations: stables, dairy premises, piggeries, poultry houses, etc.
Azamethiphos is highly effective against susceptible houseflies and it kills them very quickly. It acts mostly by oral ingestion. This means that the contact (or tarsal) effect is usually insufficient against bloodsucking flies.Azamethiphos(CAS NO:35575-96-3) was previously used as a pesticidal spray for control of flies and cockroaches in warehouses and other buildings, but the authorisation was withdrawn by Commission Regulation Interestingly.
Azamethiphos as a bait shows an excellent efficacy against certain housefly populations resistant to other organophosphates and carbamates. However, there are also housefly strains that are specifically resistant to azamethiphos, apparently because they simply avoid the sugar in the scatter baits or added to the concentrates to increase its attractiveness for houseflies.
Azamethiphos (CAS NO:35575-96-3)also has efficacy against some poultry mites, cockroaches and other crawling pests, but it is usually insufficient to control serious infestations. Azamethiphos is also used as a lousicide in fish farms, especially against salmon lice.
However, resistance of houseflies and other pests to all organophosphates, including azamethiphos is widespread. As a consequence, products with this active ingredient may not achieve the expected efficacy in many places. The same applies to all other organophosphates. This is also a reason for their progressive replacement with newer active ingredients with a different mode of action.
Notice. As a general rule this site does not provide information about off-label uses of antiparasitic active ingredients. In most countries veterinary doctors can prescribe a veterinary medicine for indications that are not included in its label. This is often the case for minor speciesand orphan diseases that are not investigated by pharmaceutical companies for whatever reasons.
An analytical method for the determination of residues of azamethiphos in salmon tissues based on HPLC with UV detection and described in the ISO 78/2 format was available. The method was of appropriate specificity and it had been shown that residues of dichlorvos, trichlofon, and the Azamethiphos metabolite 2-amino-3-hydroxy-5-chloropyridine did not interfere in the assay.
The limit of quantification was 42 µg/kg for salmon muscle and for salmon skin. Validation data for muscle with skin in natural proportions were not provided and data for accuracy and precision were provided at only 2 concentrations.
Azamethiphos is “No MRL required” therefore an analytical method for monitoring purposes is not required. No analytical method for the determination of residues of Azamethiphos in other fin fish was provided. Considering that in the previous evaluation it was concluded that no MRL was required for Salmonidae no analytical method was required for other fin fish.
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